Sir William Denys (1470–1533) of Dyrham, Gloucestershire, was a courtier of King Henry VIII and High Sheriff of Gloucestershire in 1518 and 1526.
William married 2ndly in about 1508 Anne Berkeley, da. of Maurice Berkeley(d.1506), de jure 3rd Baron Berkeley, from the leading Gloucestershire family. This marriage accorded to William a considerable status in the county gentry. The marriage took place about two years after the death of Anne's father, so it appears the marriage was arranged between William and Anne's brother Maurice Berkeley(d.1526), de jure 4th Baron Berkeley. Since 1492 the Berkeleys had been dispossessed of their ancestral lands including Berkeley Castle , following the death of William Berkeley(d.1492), 1st Marquis Berkeley, Anne's uncle, who had bequeathed all his paternal lands to King Henry VII and his heirs male, either in exchange for his new marquessate or because he disapproved of his brother Maurice having married beneath the nobility to Isabel Mead, the daughter of Philip Meade, alderman & mayor of Bristol. Anne's father Maurice, during this Berkeley exile, had therefore been living at Thornbury, close to the Denys manors of Alveston and Earthcott Green. It may have been from this proximity that the marriage was proposed.